Super-resolution structured illumination microscopy (SR-SIM) is one of the important techniques that are most suitable for live-cell imaging. The reconstructed SR-SIM images are noisy once the raw images are recorded with low-light exposure. Here. we propose a new network (entitled the ND-SIM network) to denoise the SR images reconstructed using frequency-domain algorithms (FDAs). https://pipingrockers.shop/product-category/huperzine-a/