BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR). a traditional herbal medicine. prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages. https://www.roneverhart.com/Freeze-Pipe-Glycerin-Blunt-Tip/