Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO). iron. and biliverdin (BV). the latter of which is converted to bilirubin (BR) by biliverdin reductase. https://www.roneverhart.com/Dr-Squish-Squishy-Refill/